Medical technological advancements have transformed the profession of neurosurgery, particularly in the context of brain tumor diagnosis and treatment. CHARM (Cryosection Histopathology Assessment and Review Machine) is one of the most recent developments. Scientists created this ground-breaking technique to swiftly identify a brain tumor and its molecular identities during surgery. CHARM provides informed decisions on the degree of brain tissue excision and the administration of tumor-killing medications by giving neurosurgeons important real-time information. Hence, this Harvard Medical School article discusses the capabilities of the tool and suggests how it provides real-time brain tumor diagnosis during surgery.
The article begins by stating that scientists have created an AI tool called CHARM that is capable of speedily decoding the DNA of a brain tumor during surgery. This vital information, which often takes days to weeks to gather, assists neurosurgeons in making informed decisions about how much brain tissue to remove and whether to inject tumor-killing medications directly into the brain during the surgery. According to the article, correct molecular identification is critical since removing too much tissue might damage a patient’s cognitive function, while remaining aggressive tumor cells can result in fast development. Present clinical practice does not allow for the genetic profiling of malignancies during surgery. However, CHARM solves this barrier by collecting biological signals from frozen pathology slides, allowing for real-time molecular diagnosis. Identifying a tumor’s molecular identity after surgery is also useful for on-the-spot drug-coated wafer therapy. According to the article, this instrument is compatible with the World Health Organization’s new categorization system for identifying and grading gliomas, the most aggressive and frequent kind of brain cancer. Finally, the capacity of CHARM to speed molecular diagnostics during surgery offers promise for enhancing precision oncology and post-operative choices, according to the article. Its real-time capabilities and promise for broader cancer profiling make it a desirable tool in locations where genetic sequencing technology is unavailable.
CHARM, a ground-breaking AI technology, promises to transform brain tumor surgery by instantly decoding a tumor’s DNA during surgery, delivering key molecular identification information. The above paragraph summarizes the tool’s insights based on Harvard Medical School research.
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